Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities. An artesunate suppository that can be given by minimally skilled persons might be of value when patients suddenly become too ill for oral treatment but are several hours from a facility that can give injectable treatment for severe disease. In such situations, by default, no treatment is (or can be) given until the patient (...) reaches a facility, making the placebo control design clinically relevant; alternative bioequivalence designs at the facility would misrepresent reality and risk incorrect conclusions. We describe the ethical issues underpinning a placebo-controlled trial in severe malaria. To protect patients and minimise risk, all patients were referred immediately to hospital so that each had a higher chance of prompt treatment through participation. There was no difference between artesunate and placebo in patients who reached clinic rapidly; among those who could not, a single artesunate suppository significantly reduced death or permanent disability, a finding of direct and indirect benefit to patients in participating villages and elsewhere. (shrink)

Housed in one volume for the first time are several of the seminal essays on Du Bois's contributions to sociology and critical social theory: from DuBois as inventor of the sociology of race to Du Bois as the first sociologist of American religion; from Du Bois as a pioneer of urban and rural sociology to Du Bois as innovator of the sociology of gender and culture; and finally from Du Bois as groundbreaking sociologist of education and cultural criminologist to Du (...) Bois as critic of the disciplinary decadence of the discipline of sociology. Unlike any other anthology or critical reader on Du Bois, this new volume offers an excellent overview of the critical commentary on arguably one of the most imaginative and innovative, perceptive and prolific founders of the discipline of sociology. (shrink)

We describe in some detail how to build an infinite computing machine within a continuous Newtonian universe. The relevance of our construction to the Church-Turing thesis and the Platonist-Intuitionist debate about the nature of mathematics is also discussed.

A moving cultural biography of abolitionist martyr John Brown, by one of the most important African-American intellectuals of the twentieth century. In the history of slavery and its legacy, John Brown looms large as a hero whose deeds partly precipitated the Civil War. As Frederick Douglass wrote: "When John Brown stretched forth his arm... the clash of arms was at hand." DuBois's biography brings Brown stirringly to life and is a neglected classic.

A dialogue between a foreign philosopher and a powerful statesman outline Plato's reflections on the family, the status of women, property rights, and criminal law.

The regular increase in the proportion of resolved feet in the iambic trimeters of Euripides' later plays was first commented upon in 1807 by J. Gottfried Hermann, who therefrom deduced the principle that the date of any play of Euripides could be directly determined from the frequency of its resolutions. This criterion he restated in several of his works in the following years, and when Elmsley objected that it was of uncertain value on account of the small number of plays (...) of certain date by which it might be verified, he replied with a strong defence of his case: he did not, however, develop his principle in detail or give figures in its support. The first scholar to publish the totals of trisyllabic feet in each play was Zirndorfer: relying largely on these, he produced a chronology of Euripides' dramatic composition in several respects superior to any predecessor's. His conclusions were questioned by C. F. W. Müller, who, while accepting Hermann's thesis as being in general correct, doubted its reliability for determining the exact period of a tragedy's composition. Consequently, although he gave the totals of trisyllabic feet en passant, Müller made no attempt to suggest dates. At almost the same time as Müller's treatise appeared, J. Rumpel published an article giving a full and detailed list of references to all trisyllabic feet in Euripides: from this evidence he divided the dramas into four age-groups, but did not go so far as to assign specific dates. (shrink)

The ideas and methods of cybernetics are increasingly penetrating the biological and medical sciences, and today we are justified in speaking of a new branch of science: biological and medical cybernetics. This branch already has a number of important and encouraging subfields.

This book offers a critical evaluation of Weber's ideology of value-choice. The author establishes Weber's ideology and then considers it in light of his sociological methodology. He also weighs the critical assessments of Weber made by Vogelin, Strauss, Aron, Gouldner, Rex, and Mommsen and examines Weber's misperceptions concerning natural law and moral and political philosophy.

I examine Popper’s claims about Newton’s use of induction in Principia with the actual contents of Principia and draw two conclusions. Firstly, in common with most other philosophers of his generation, it appears that Popper had very little acquaintance with the contents and methodological complexities of Principia beyond what was in the famous General Scholium. Secondly Popper’s ideas about induction were less sophisticated than those of Newton, who recognised that it did not provide logical proofs of the results obtained using (...) it, because of the possibilities of later, contrary evidence. I also trace the historical background to commonplace misconceptions about Newton’s method.Author Keywords: Newton; Popper; Induction; Principia; Kepler’s laws. (shrink)